For most of psychiatry’s history, mental illness and metabolic health have been treated as separate problems, seen by separate doctors, on separate charts. Dr. Shebani Sethi disagreed.

In 2015, she founded Stanford’s first academic Metabolic Psychiatry program and conceived the term itself, building a clinical discipline around a simple premise: the brain runs on metabolism, and treating one without the other leaves patients half-treated.

For our first Leading Voices Q&A, we sat down with her to talk about what that means for digital health.

People with serious mental illness die 10 to 20 years earlier than the general population, not due to suicide as might be the assumption, but largely by preventable physical health problems such as heart disease, diabetes, and other metabolic conditions. That fact alone should change how we practice psychiatry.

Metabolic psychiatry is the clinical practice of treating the metabolic drivers of mental illness alongside psychiatric symptoms. Metabolic dysfunction like insulin resistance, lipid dysregulation, mitochondrial dysfunction and chronic inflammation are not just comorbidities in serious mental illness. They contribute to the development, progression, and treatment resistance of mental illness.

Traditional psychiatry treats the brain in isolation. Metabolic psychiatry treats the brain as a metabolic organ. That distinction changes the interventions, the monitoring and the outcomes we can achieve.

This field needed its own category because it is not nutritional psychiatry, functional medicine or lifestyle medicine. It is an integrative clinical approach that bridges neuroscience, endocrinology, immunology, and nutritional science, conceptualizing mental disorders as disturbances in brain-body energy regulation. I founded the first academic metabolic psychiatry program at Stanford in 2015 to build the research base, and Metabolic Psychiatry Labs exists to translate that research into scalable clinical care.

We are at an inflection point where clinical evidence, metabolic science and digital infrastructure are converging in a way that makes this model both testable and scalable.

Our narrative review in Nature Mental Health synthesizes evidence across psychiatry, neuroscience and metabolic medicine to define metabolic psychiatry as a clinical framework and field of study. It reflects growing alignment across disciplines that metabolic dysfunction is not peripheral, but central to how we understand serious mental illness. The paper highlights the bidirectional relationship between metabolic state and brain function, where changes in one directly influence the other.

This builds on our earlier clinical trial published in the Journal of Psychiatric Research, which studied patients with bipolar disorder and schizophrenia who had not responded adequately to conventional treatments. Within four months of a ketogenic metabolic therapy protocol, 79% showed clinically significant psychiatric improvement. All participants met criteria for reversal of metabolic syndrome, and the group lost an average of 10% body weight in four months.

What matters here is not just the psychiatric outcomes. It is that metabolic and psychiatric improvement occurred together, which supports the core thesis: these conditions share a common metabolic root.

The gap between a clinical trial and a care model is where most innovations stall, especially in psychiatry. We built MPL and our MetBloom approach specifically to bridge that gap.

Our MetBloom model is telehealth-first and built as a coordinated care system. A patient receives a full psychiatric evaluation, comprehensive metabolic biomarker testing, and a personalized treatment plan that may include ketogenic metabolic therapy, medication optimization, and ongoing real-time data monitoring. The care team works together across psychiatry and metabolic medicine rather than in silos.

We treat serious mental illness: major depressive disorder, bipolar disorder, and schizophrenia. These are patients who have often tried multiple medications without adequate response. We accept insurance and deliver care remotely, which removes the geographic and access barriers that typically keep people from specialized psychiatric care.

Technology is not an add-on for us. It is the infrastructure that makes metabolic psychiatry scalable.

Traditional psychiatric care is built around episodic visits and limited data. Metabolic psychiatry relies on continuous streams of biological and behavioral information: metabolic indicators, mood, sleep, glucose and medication response, all tracked in real time. Managing this level of complexity requires an integrated system, not isolated clinical encounters.

Our platform gives patients a single interface for tracking their metabolic and psychiatric data and staying connected to their care team between visits. For clinicians, it creates a continuous data stream that supports earlier intervention and more informed decision-making across psychiatry and metabolic medicine.

To our knowledge, this is the first platform built specifically for metabolic psychiatry.

It connects physiology with symptoms on an ongoing basis, which is something traditional psychiatric care has not been structured to do. That is what allows this model to scale beyond a single clinic and function as a care platform.

The short-term path is continued clinical validation and expanding access. We are actively treating patients across multiple states, and the evidence base is growing with publications in journals like Nature Mental Health, Biological Psychiatry, Journal of Affective Disorders, Journal of Psychiatric Research. More clinicians and researchers are entering the field every year.

The longer-term vision is a fundamental shift in how we understand and treat serious mental illness. Right now, psychiatry largely treats symptoms with medication. Metabolic psychiatry offers a model that addresses root-cause biology, and early results suggest this should be part of the standard of care conversation.

From a healthtech perspective, this is a shift from episodic, symptom-based care to continuous, biology-informed care. When you combine real-time metabolic data, remote monitoring and coordinated clinical teams, the model moves beyond symptom management toward stabilizing the underlying metabolic drivers.

At a systems level, this approach has the potential to reduce treatment resistance, improve quality of life and address the excess mortality seen in serious mental illness.

As the evidence base grows, the question becomes how quickly this can be integrated into standard care.

If you or someone you know is living with a serious mental illness, we are now accepting patients and on select insurance plans. Learn more at our website!

Dr. Shebani Sethi, MD, ABOM - Founding Director of Stanford’s Metabolic Psychiatry Clinic, Founder of Metabolic Psychiatry Labs and Psychiatrist

Thanks for reading DHI’s HealthTech Expert Q&A!

We hope you’ve learned as much as we did with this piece.

Stay tuned for next edition to keep gaining insights from various experts and stay ahead of the curve in digital health innovation!

Want to join the conversation? We’re always looking for new guest columnists to share their expertise with our audience.

Reach out if you’d like to be featured!

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4. Peptides are having a moment. Here’s what it actually takes to build in this space.

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8. Delta Dental and Midi Health Expand Partnership Connecting Menopause Care with Oral Health.

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6. Oura unveils AI-enabled Ring 5 with predictive health features.

7. Amazon taps Amwell co-founder to lead health business.

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9. Care navigation startup Garner Health banks $100M series E at $2.74B valuation.

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12. Alife Health receives FDA clearance for AI-powered embryo selection tool.

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4. HealthEx and 23andMe partner to unify medical records and genomics.

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6. Qualtrics acquires healthcare experience leader Press Ganey Forsta for $6.75 billion, expanding experience management (XM) category leadership and creating the world’s largest AI dataset for human experiential context ever assembled.

7. Maven expands virtual clinic nationwide, integrating GLP-1 and hormonal care with comprehensive women’s health.

8. Elon Musk’s Neuralink reveals new robotic system for BCI brain implant surgeries.

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11. AI ate digital health (and what that means for fundraising).

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3. Cleveland Clinic’s quantum system hits 90% capacity.

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7. Chromie Health picks up $2M in pre-seed funding, launches SMS AI-powered nurse staffing agent.

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7. Irish-American health-tech startup aims to rewire patient journeys.

8. Dandelion Health raises $14M for precision medicine platform.

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11. In real-world test, an AI model did better than doctors at diagnosing patients.

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4. WHOOP wins contract to support U.S. Navy with wearables.

5. Spotify teams up with Peloton to launch global fitness content hub.

6. Aidoc banks $150M backed by Goldman Sachs to scale clinical AI foundation model.

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8. Biohub Launches the Virtual Biology Initiative.

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4. Ozempic pill for children to launch in US market ‘soon’: Novo Nordisk.

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6. Amperos Health raises $16M for agentic AI denial management and revenue recovery platform.

7. Tava Health raises $40M for tech-enabled mental health platform.

8. A third player enters the AI arms race.

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3. Death by a Thousand Vendors: Solera Report Reveals The Hidden Costs of Digital Health.

4. CMS unveils first wave of health tech tools as it pushes data sharing initiative.

5. Walmart expands Better Care Services to include GLP-1 access.

6. BodySpec partners with longevity telehealth clinic on DEXA scans.

7. Wavelet Medical secures $7M to scale AI fetal brain monitoring globally with Aegis Ventures.

8. Ultralight Raises $9.3M to launch AI-native operating system for healthcare.

9. Abridge partners with medical journals to expand AI clinical decision support.

10. OpenAI partners with Novo Nordisk for AI drug discovery.

11. 6 Health Systems enhancing care delivery with ambient AI Scribes.

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Rune Labs builds AI-powered software that uses data from wearables, patient-reported inputs, and clinical sources to improve care for neurological conditions like Parkinson’s. Its platform tracks symptoms in real time, gives clinicians actionable insights, and aggregates data to support research and clinical trials. By turning continuous patient data into usable intelligence, Rune Labs aims to personalize treatment today while accelerating the development of new neurotherapies.

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2. Medvi, the AI-powered telehealth company, is fueled by ads from doctors who don’t appear to exist.

3. Healthcare remains top cybercrime target: FBI.

4. Signature Healthcare cyber incident not expected to be resolved soon.

5. Amazon Pharmacy partners with Eli Lilly to offer Foundayo GLP-1 with same-day delivery.

6. b.well announces partnerships with Noom, Humana, Welldoc.

7. Talkiatry launches Talkiatry Connect for cloud-based EMR psychiatric referrals.

8. Click Therapeutics Secures $50M to commercialize schizophrenia digital therapeutic.

9. Sub-Q Bionics raises $1.5M and signs Mayo Clinic licensing deal to develop Implantable Lymphedema Device.

10. Luminai raises $38M to scale AI workflow automation platform.

11. AI-enabled smart sensor identifies fatigue.

12. Qventus Report: 94% of Healthcare CIOs say AI delays create competitive disadvantage.

April 13-16th | Chicago, IL.
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Biorce develops AI-powered simulation technology that helps pharmaceutical companies design and optimize clinical trials before they run. Its platform creates virtual patient cohorts using biological, clinical, and real-world data to predict trial outcomes, refine protocols, and test different scenarios. By identifying risks and improving study design upfront, Biorce aims to reduce trial failures, shorten timelines, and lower development costs.

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1. Top news in Digital Health from March 2026.

2. FDA approves Eli Lilly’s GLP-1 pill for weight loss.

3. The tortoise and the hare of care: Health AI insights from Rock Health’s 2025 Consumer Adoption Survey.

3. Cleveland Clinic pilots EHR-integrated AI for inpatient nursing.

4. Announcing Stedi’s $50 million Series C.

5. eMed Secures $200M Series A at $2B+ Valuation to Scale AI-Powered GLP-1 Employer Platform.

6. WHOOP raises $575M, hits $10.1B valuation.

7. myStoria raises $1.625M to build care coordination platform for reproductive health patients.

8. 2026 Physician Survey on Augmented Intelligence.

9. Changes in clinician time expenditure and visit quantity with adoption of artificial intelligence–powered scribes.

10. Penguin Ai Launches Gwen, a Build-Your-Own AI Platform for Healthcare Operations.

April 7-9th | Las Vegas, NA.
2026 USA Health Summit.

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DiaDia Health develops an AI-powered clinical reasoning platform focused on women’s endocrine, metabolic, and hormonal health. The system analyzes genetics, lab results, and clinical history to identify root causes behind complex or “unexplained” symptoms, generating personalized insights and treatment pathways. Designed for both clinicians and patients, it aims to reduce diagnostic trial-and-error and bring greater precision to conditions often missed by standard lab ranges.

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1. Allina Health to join Sutter Health in $26B proposed transaction.

2. Balancing AI innovation and risk: 5 takeaways from HIMSS26.

3. Imperative Care secures $100M to automate stroke treatment, develop endovascular robotics platform.

4. Mave Health raises $2.1M to launch focus and stress regulation wearable.

5. 2026 Physician Survey on Augmented Intelligence.

6. Verily banks $300M to accelerate AI road map, transitions to independent company.

7. Google unveils medical records integration in Fitbit app at Check Up event.

8. Health systems can’t AI their way out of bad data.

9. Exclusive: Health Universe raises $6M for AI agents for medical workflows.

10. March 28-29 | Los Angeles, CA.
    Biohackers.

Until next week, stay connected!

Digital Health Insider.

Kingdom is a telehealth platform focused on personalized health optimization. Co-founded by Jay Cutler, the company offers clinician-guided hormone therapies, weight loss programs, peptides, and wellness services designed to improve energy, focus, and overall performance.
With its latest relaunch, Kingdom expands beyond men’s health to serve both men and women - built for those who refuse to let “normal” define their potential.

Hey there Insider,

Hope you had a fantastic week!

Here’s your must-read weekly roundup of the latest news and developments in the digital healthcare sector! 👇🏼

1. Snowflake research reveals 85% of healthcare leaders view interoperability as foundational to scaling AI.

2. AI, responsibility, and the recurring panic about software: Thought leadership piece.

3. Stryker cyberattack tied to Iran: 10 updates.

4. Maven Clinic launches direct-to-consumer platform nationwide featuring GLP-1 and hormone care.

5. ARPA-H launches program to develop biosensors that can track multiple signals.

6. Arya raises $21M for AI-Powered couples wellness platform.

7. Wisp launches women-focused longevity and healthy aging vertical.

8. Translucent announces $27M series A led by GV to tackle healthcare’s existential financial crisis.

9. The AI pilot era is over for health systems.

10. From insights to action: Innovaccer partners with databricks to operationalize healthcare AI at enterprise scale.

11. Safety-net providers tackle AI adoption as Medicaid cuts loom.

March 16 - 17 | Philadelphia, PA
Pharma USA 2026.

Until next week, stay connected!

Digital Health Insider.

Visible builds digital tools that help people manage long-term conditions such as Long Covid and ME/CFS. Its platform combines a mobile app, symptom tracking, and wearable data to help users understand energy levels, pace daily activity, and avoid symptom flare-ups. By translating physiological signals and self-reported data into clear insights, Visible aims to support better self-management for people living with complex chronic illnesses.

Hey there Insider,

Hope you had a fantastic week!

Here’s your must-read weekly roundup of the latest news and developments in the digital healthcare sector! 👇🏼

1. Top news in Digital Health from February 2026.

2. Provider groups push to preserve some IT certification criteria, including AI ‘model cards’.

3. Chutes & Ladders—Beth Israel Lahey Health CEO, president to step down; Stellar Health names new CFO.

4. Sage raises $65M to expand AI senior care platform to prevent falls.

5. CVS, Google Cloud partner on healthcare consumer engagement platform.

6. Amazon launches Amazon Connect Health.

7. Grow Therapy secures $150M for mental health platform.

8. Cognito Therapeutics raises $105M for neurotechnology platform for Alzheimer’s.

9. Eight Sleep raises $50M at $1.5B valuation to expand into ‘Predictive, AI-Driven Health’.

10. Accelerating AI innovation in healthcare: real-world clinical research applications on the Mayo Clinic Platform.

11. AWS launches a new AI agent platform specifically for healthcare.

12. Salesforce partners with HealthEx, Verily and Viz.ai to build out healthcare AI agents.

March 9-12th | Las Vegas, NV.
HiMSS Global Health Conference - Light-it’s team will be there!

Until next week, stay connected!

Digital Health Insider.